{"id":7355,"date":"2026-10-08T14:21:23","date_gmt":"2026-10-08T12:21:23","guid":{"rendered":"https:\/\/stiftkgj.no\/?post_type=senter&#038;p=7355"},"modified":"2026-10-13T11:14:12","modified_gmt":"2026-10-13T09:14:12","slug":"k-g-jebsen-center-for-epimutations-in-cancer","status":"publish","type":"senter","link":"https:\/\/stiftkgj.no\/en\/senter\/k-g-jebsen-center-for-epimutations-in-cancer\/","title":{"rendered":"K.G. Jebsen Center for Epimutations in Cancer"},"content":{"rendered":"<div class=\"wpb-content-wrapper\"><p>[vc_row css=&#8221;.vc_custom_1651580050061{margin-right: 0px !important;margin-left: 0px !important;background-image: url(https:\/\/stiftkgj.no\/wp-content\/uploads\/2022\/04\/Topp-bilde-2.jpg?id=427) !important;background-position: center !important;background-repeat: no-repeat !important;background-size: cover !important;}&#8221;][vc_column]<div class=\"spacer-5830a5ea62c1f2880975a2ceab4a96be2\" style=\"\"><\/div><style>@media (min-width: 320px) { .spacer-5830a5ea62c1f2880975a2ceab4a96be2{ height: 200px;}}@media (min-width: 767px) { .spacer-5830a5ea62c1f2880975a2ceab4a96be2{ height: 200px;}}@media (min-width: 979px) { .spacer-5830a5ea62c1f2880975a2ceab4a96be2{ height: 400px;}}@media (min-width: 1200px) { .spacer-5830a5ea62c1f2880975a2ceab4a96be2{ height: 400px;}}<\/style>[\/vc_column][\/vc_row][vc_row el_class=&#8221;article-white&#8221; css=&#8221;.vc_custom_1649536549777{margin-right: 0px !important;margin-left: 0px !important;}&#8221;][vc_column][vc_row_inner][vc_column_inner]<div class=\"spacer-f96c97828f0d47b1724343c705ecae9d423\" style=\"\"><\/div><style>@media (min-width: 320px) { .spacer-f96c97828f0d47b1724343c705ecae9d423{ height: 10px;}}@media (min-width: 767px) { .spacer-f96c97828f0d47b1724343c705ecae9d423{ height: 10px;}}@media (min-width: 979px) { .spacer-f96c97828f0d47b1724343c705ecae9d423{ height: 10px;}}@media (min-width: 1200px) { .spacer-f96c97828f0d47b1724343c705ecae9d423{ height: 10px;}}<\/style><div class=\"header left  \"><h1 class=\"font-size-sm\" title=\"K.G. Jebsen Center for Epimutations in Cancer\" style=\"color:#0054a2\">K.G. Jebsen Center for Epimutations in Cancer<\/h1><\/div>[\/vc_column_inner][\/vc_row_inner][vc_row_inner][vc_column_inner width=&#8221;3\/4&#8243;][vc_single_image image=&#8221;7342&#8243; img_size=&#8221;full&#8221; css=&#8221;&#8221;][vc_column_text css=&#8221;&#8221;]Western societies are facing a cancer epidemic. Even after accounting for an ageing population, cancer incidence is rising at an alarming rate. This development has occurred over just a few decades and therefore cannot be explained by genetic changes in the population. Instead, the causes must be linked to environmental and lifestyle factors, yet we still know little about the biological mechanisms connecting these factors to increased cancer risk.<\/p>\n<div>\n<p>At the K.G. Jebsen Centre for Epimutations in Cancer, researchers will investigate this challenge in a new way. The Centre is built on groundbreaking discoveries showing that epigenetic alterations, known as epimutations, occurring early in embryonic development may be an underlying cause of a significant proportion of cancer cases. Researchers behind the Centre have demonstrated that embryonic epimutations in the BRCA1 gene are present in 5-10% of healthy women and contribute to the development of a substantial share of breast and ovarian cancer cases.<\/p>\n<p>The origins of such embryonic epimutations remain largely unexplored. One important reason is that the methods used so far have not been sensitive enough to detect these changes. At the Centre, researchers will employ specially developed sequencing-based analyses to identify and study epimutations with far greater precision. Through a comprehensive research programme, they will investigate how widespread epimutations in tumour suppressor genes are, what causes them, and how they contribute to cancer development.<\/p>\n<p>The results may provide new insights into how many forms of cancer arise and thereby change our understanding of the origins of the disease. The findings may also have major implications for cancer prevention and lay the foundation for new treatment strategies for cancers driven by epigenetic mechanisms.<\/p>\n<p>The K.G. Jebsen Centre for Epimutations in Cancer is based at the Department of Clinical Science, University of Bergen, and the Department of Oncology and the Department of Obstetrics and Gynecology at Haukeland University Hospital.<\/p>\n<p><strong>Centre Director:<\/strong><br \/>\n<a class=\"fui-Link fai-bebop ___1myvvpj f2hkw1w f3rmtva f1ewtqcl f16muhyy f1k6fduh f1w7gpdv f1mo0ibp fjoy568 ff5ikls f1s184ao f1mk8lai fnbmjn9 f1o700av f13mvf36 f33ey8m f9n3di6 f1ids18y f1tx3yz7 f1bwia3u f1eh06m1 f1xeumsx fhgqx19 f1olyrje f1p93eir f1nev41a f132whgj f1v74mp6 f1tsf1ni fnq52rx f16zlvvm\" tabindex=\"0\" href=\"https:\/\/www4.uib.no\/en\/find-employees\/stian.knappskog\" target=\"_blank\" rel=\"noopener noreferrer\" data-tabster=\"{&quot;restorer&quot;:{&quot;type&quot;:1}}\">Stian Knappskog<\/a><\/p>\n<p><strong>Deputy Directors:<\/strong><br \/>\n<a class=\"fui-Link fai-bebop ___1myvvpj f2hkw1w f3rmtva f1ewtqcl f16muhyy f1k6fduh f1w7gpdv f1mo0ibp fjoy568 ff5ikls f1s184ao f1mk8lai fnbmjn9 f1o700av f13mvf36 f33ey8m f9n3di6 f1ids18y f1tx3yz7 f1bwia3u f1eh06m1 f1xeumsx fhgqx19 f1olyrje f1p93eir f1nev41a f132whgj f1v74mp6 f1tsf1ni fnq52rx f16zlvvm\" tabindex=\"0\" href=\"https:\/\/www4.uib.no\/en\/find-employees\/camilla.krakstad\" target=\"_blank\" rel=\"noopener noreferrer\" data-tabster=\"{&quot;restorer&quot;:{&quot;type&quot;:1}}\">Camilla Krakstad<\/a><br \/>\n<a class=\"fui-Link fai-bebop ___1myvvpj f2hkw1w f3rmtva f1ewtqcl f16muhyy f1k6fduh f1w7gpdv f1mo0ibp fjoy568 ff5ikls f1s184ao f1mk8lai fnbmjn9 f1o700av f13mvf36 f33ey8m f9n3di6 f1ids18y f1tx3yz7 f1bwia3u f1eh06m1 f1xeumsx fhgqx19 f1olyrje f1p93eir f1nev41a f132whgj f1v74mp6 f1tsf1ni fnq52rx f16zlvvm\" tabindex=\"0\" href=\"https:\/\/www4.uib.no\/en\/find-employees\/halfdan.sorbye\" target=\"_blank\" rel=\"noopener noreferrer\" data-tabster=\"{&quot;restorer&quot;:{&quot;type&quot;:1}}\">Halfdan S\u00f8rbye<\/a><\/p>\n<\/div>\n<p>[\/vc_column_text][vc_single_image image=&#8221;7349&#8243; img_size=&#8221;full&#8221; add_caption=&#8221;yes&#8221; css=&#8221;&#8221;]<div class=\"external-links-container light-blue\"><ul class=\"external-links\"><\/ul><\/div>[\/vc_column_inner][vc_column_inner width=&#8221;1\/4&#8243;]<div class=\"infobox light-brown\"><h3>The Centre in brief<\/h3>\n<div class=\"wpb_text_column wpb_content_element \">\n<div class=\"wpb_wrapper\">\n<p id=\"hdr\">Leader: stian Knappskog<br \/>\nStart year: 2026<br \/>\nHost institution: University of\u00a0 Bergen<br \/>\nFunding from the foundation: 25 MNOK<br \/>\nHome page:\u00a0 &#8211; will come soon-<\/p>\n<\/div>\n<\/div>\n<\/div><div class=\"infobox light-brown\"><h3>Scientific advisory board<\/h3><p>Johan Staaf, Lund University<br \/>\nTim Fenton, University of Southampton<br \/>\nVioleta Serra, AstraZeneca, Barcelona<\/p><\/div>[\/vc_column_inner][\/vc_row_inner][\/vc_column][\/vc_row][vc_row][vc_column]<div class=\"spacer-19ba46bd32479517faefa95d8bc53e873425752342356\" style=\"\"><\/div><style>@media (min-width: 320px) { .spacer-19ba46bd32479517faefa95d8bc53e873425752342356{ height: 30px;}}@media (min-width: 767px) { .spacer-19ba46bd32479517faefa95d8bc53e873425752342356{ height: 30px;}}@media (min-width: 979px) { .spacer-19ba46bd32479517faefa95d8bc53e873425752342356{ height: 60px;}}@media (min-width: 1200px) { .spacer-19ba46bd32479517faefa95d8bc53e873425752342356{ height: 60px;}}<\/style>[\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>The research at K.G. Jebsen Centre for epimutations in cancer, lead by Stian Knappskog, has the potential to fundamentally transform our understanding of how cancer develops, including by investigating whether changes that occur early in embryonic development can lead to cancer later in life. [&#8230;]<\/p>\n<p><a class=\"btn btn-secondary vidiflex-read-more-link\" href=\"https:\/\/stiftkgj.no\/en\/senter\/k-g-jebsen-center-for-epimutations-in-cancer\/\">Read More&#8230;<\/a><\/p>\n","protected":false},"featured_media":7361,"template":"","categories":[32],"class_list":["post-7355","senter","type-senter","status-publish","has-post-thumbnail","hentry","category-medical-research"],"acf":[],"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/stiftkgj.no\/en\/wp-json\/wp\/v2\/senter\/7355","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/stiftkgj.no\/en\/wp-json\/wp\/v2\/senter"}],"about":[{"href":"https:\/\/stiftkgj.no\/en\/wp-json\/wp\/v2\/types\/senter"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/stiftkgj.no\/en\/wp-json\/wp\/v2\/media\/7361"}],"wp:attachment":[{"href":"https:\/\/stiftkgj.no\/en\/wp-json\/wp\/v2\/media?parent=7355"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/stiftkgj.no\/en\/wp-json\/wp\/v2\/categories?post=7355"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}